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KMID : 1011220170030010012
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Clinical & Experimental Thrombosis and Hemostasis
2017 Volume.3 No. 1 p.12 ~ p.15
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Interplay of Leukocyte, Endothelial Cell and Platelet in Hemorrhage and Hemostasis
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Song Jae-Woo
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Abstract
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The canonical hemostatic function of platelet includes the formation of hemostatic aggregate which then is reinforced by intervening and wrapping fibrin clot. It explains well how our bodies react to direct and physical insults to tissues and vessels therein. On the other hand, vascular integrity is often breached in rather occult manners such as inflammation associated bleeding of thrombocytopenic patients. Bleeding in animals induced by manipulation of certain genes can also be regarded as such. In these cases, the picture of hemostasis is different from conventional understanding. Numbers of experimental results were published regarding the role of leukocytes in thrombus formation. Considering that most occlusive vascular diseases harbor inflammatory components as pathogenic mechanism, the involvement of leukocytes in thrombosis is not astonishing. Interestingly, leukocytes are also involved hemorrhagic manifestation of thrombocytopenia or inflammatory disease animal models. An intriguing aspect of those studies is that hemorrhage is strongly associated with leukocyte extravasation both chronologically and geographically. Whether a passage of leukocyte through the vessel wall functions as the channel of hemorrhage is not known. The exact role of platelets in preventing this kind of bleeding is also still unkown. The link between platelet aggregation and the vascular integrity is seemingly absent in those studies. Evidences still need to accumulate for mechanistic understanding of this new kind of hemostasis.
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KEYWORD
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Hemorrhage, Leukocyte, Diapedesis, Endothelial Cell, Platelet
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